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Intrauterine insemination aided with ovulation induction with gonadotropins (Bravelle, Repronex, Follistim, and Gonal-F) may benefit couples who have not conceived after an appropriate time with routine therapy and all infertility factors corrected. This applies to couples in which the wife has one or more open tubes with an ovulatory problem, unexplained infertility, or minimal endometriosis.

Intrauterine insemination(s), along with ovulation induction with gonadotropins, appear to improve pregnancy chance due to increasing the number of available eggs and sperm to maximize the chance of pregnancy to approximately 15 to 20% per attempt. Multiple gestations occur at a rate similar to IVF; however, rarely quadruplets or greater can occur.

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